Key result
Elevated β-hydroxybutyrate levels and a ketogenic diet exacerbated cardiomyocyte death and cardiac dysfunction under hypoxic conditions by inhibiting HIF-1α-dependent glycolysis.
Why the study?
Whether an increased ketone body supply in hypoxic cardiomyocytes and ischemic hearts is protective remains elusive.
Does β-hydroxybutyrate (β-OHB) or a ketogenic diet exacerbate hypoxic injury and cardiac dysfunction in cardiomyocytes and myocardial infarction models?
Does β-hydroxybutyrate (β-OHB) or a ketogenic diet exacerbate hypoxic injury and cardiac dysfunction in cardiomyocytes and myocardial infarction models?
Elevated β-OHB levels and ketogenic diets may be maladaptive during myocardial infarction by inhibiting HIF-1α-dependent glycolysis, suggesting caution for ketogenic diets in ischemic heart disease.
No takes yet. Share an insight, caveat, or question.
Ketogenic diets may worsen hypoxic cardiac injury; hypothesis-generating for β-hydroxybutyrate effects on HIF-1α in humans.
Ma et al. (2021) studied Acute myocardial infarction and hypoxic myocardial injury (n=77). Ketogenic diet and β-hydroxybutyrate vs. Chow diet or vehicle control was evaluated on Cardiomyocyte death and cardiac dysfunction under hypoxia. Elevated β-hydroxybutyrate levels and a ketogenic diet exacerbated cardiomyocyte death and cardiac dysfunction under hypoxic conditions by inhibiting HIF-1α-dependent glycolysis.
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