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November 1, 1985Journal of Clinical InvestigationOpen Access

Metabolic fate of extracted glucose in normal human myocardium.

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Population

23 healthy male volunteers

Design

Other

Authors

JWJ A WisneskiEGEdward W. GertzRNRichard A. Neese

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Overview

Supports reciprocal substrate use in normal human myocardium; leaves open relevance to metabolic therapies in disease.

Structured PICO

P
Population
23 healthy male volunteers
I
Intervention
Infusion of [6-14C]Glucose (n=10) or simultaneous [6-14C]Glucose and [U-13C]lactate (n=13) with coronary sinus and arterial catheterization
O
Outcome
Myocardial glucose extraction, oxidation, and metabolic fatesurrogate

In normal human myocardium, circulating free fatty acids inversely correlate with glucose extraction and oxidation, with the majority of extracted glucose likely stored as glycogen in the fasting, resting state.

Cite This Study

Wisneski et al. (1985) studied this question.

synapsesocial.com/papers/6a6fc3a53ce530166bc2aebahttps://doi.org/10.1172/jci112174
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Also Consider

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  1. 1Effect of fasting on glucose and palmitate metabolism of perfused rat heart1963 · 75 citations
  2. 2Comparison of the Effects of Anoxia and Whole Heart Ischemia on Carbohydrate Utilization in Isolated Working Rat Hearts1973 · 293 citations
  3. 3Effect of Glucose-Insulin-Potassium Infusion on Myocardial Infarction following Experimental Coronary Artery Occlusion1972 · 295 citations
  4. 4Effects of Alpha Adrenergic Blockade upon Coronary Hemodynamics1978 · 85 citations
  5. 5Regulation of Coronary Blood Flow1964 · 394 citations