Key result
Pacing-induced myocardial ischemia was associated with augmented glucose extraction, which correlated significantly with lactate production (r = 0.81; P < 0.001).
Why the study?
Does coronary sinus pacing stress alter myocardial glucose extraction in subjects undergoing cardiac catheterization?
Population
27 subjects undergoing diagnostic cardiac catheterization who had fasted overnight
Comparison
Coronary sinus pacing stress vs Resting state (before pacing)
Design
Other
Authors
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May reflect ischemia-driven metabolic shifts during catheterization; leaves open causal role and clinical relevance.
Observational (n=27)
Does coronary sinus pacing stress alter myocardial glucose extraction in subjects undergoing cardiac catheterization?
Effect estimate: r = 0.81
p-value: p=< 0.001
Myocardial ischemia in humans is associated with augmented glucose extraction, which correlates with lactate production but not arterial glucose concentration.
Most et al. (1972) conducted an observational in Ischemic human myocardium (n=27). Coronary sinus pacing vs. Rest was evaluated on Correlation between glucose extraction and lactate production during pacing in groups with pacing-induced ischemia (r = 0.81, p=< 0.001). Pacing-induced myocardial ischemia was associated with augmented glucose extraction, which correlated significantly with lactate production (r = 0.81; P < 0.001).
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