Why the study?
Does myocardial lactate extraction change and is there simultaneous uptake and release of lactate in the normal human heart at rest and during exercise?
Population
13 healthy young male volunteers
Comparison
Infusion of 14C lactate with measurements at… vs Within-subject comparisons across different states
Design
Other
Authors
Loading...
Supports lactate uptake without release in normal hearts; hypothesis-generating for metabolic changes in disease or prolonged stress.
Does myocardial lactate extraction change and is there simultaneous uptake and release of lactate in the normal human heart at rest and during exercise?
During short-term heavy exercise, myocardial lactate extraction dominates over other substrates for oxidation by heart muscle cells, with no evidence of simultaneous lactate release.
Kaijser et al. (1992) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: