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To investigate the relationship of myocardial lactate extraction with metabolic parameters during increased heart rates.

February 1, 1980Circulation

Myocardial lactate extraction: multi-determined metabolic function.

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To investigate the relationship of myocardial lactate extraction with metabolic parameters during increased heart rates.
Sixteen healthy young males underwent coronary sinus and arterial catheterization.
Blood samples for lactate, free fatty acids, and glucose were obtained at rest and during pacing.
Hemodynamic measurements and lactate extraction rates were analyzed.
44% of subjects had lactate extraction of less than 10% at rest and/or maximal pacing.
Lactate extraction had an inverse correlation with arterial free fatty acids (r = 0.67; p < 0.01).
A positive correlation was observed between lactate extraction and arterial lactate levels (r = 0.78; p < 0.01).

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Randomized trial examines lactate extraction changes during pacing in healthy males, indicating complex metabolic regulation.

Gertz et al. (1980) studied this question.

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