Population
Dogs subjected to high ligation of the circumflex branch of the left coronary artery
Comparison
Ischemia induced by high ligation of the… vs Non-ischemic tissue from the anterior superior…
Design
Preclinical
Follow-up
24 hours
Authors
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May inform reperfusion timing in acute ischemia; leaves open translation from animal models to human therapeutics.
Ischemia causes a rapid decline in oxidative metabolism in affected cardiac tissue within 60 minutes, with complete loss by 24 hours, alongside a compensatory increase in non-ischemic tissue.
KALTENBACH et al. (1960) studied this question.
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