What does this research mean for the field?

Following acute coronary artery occlusion, ischemic myocardium rapidly depletes energy-rich phosphates and accumulates glycolytic metabolites, while nonischemic myocardium exhibits early enzymatic increases indicative of compensatory hyperfunction and increased energy requirements. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1968Circulation Research

Early Changes in Energy Metabolism in the Myocardium Following Acute Coronary Artery Occlusion in Anesthetized Dogs

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Population

Anesthetized dogs

Comparison

Acute coronary artery occlusion via ligation of… vs Nonischemic portions of myocardium

Design

Preclinical

Follow-up

2 hours

Authors

WBW. BraaschWayne State University SGSigmundur GudbjarnasonUniversity of Iceland PPPritpal S. PuriThe University of Queensland

Discussion

Member takes

Implication

Rapid energy depletion marks ischemic canine myocardium; hypothesis-generating for human ischemia models but should not change practice.

Structured PICO

Population

Anesthetized dogs

Intervention

Acute coronary artery occlusion via ligation of branches of the anterior descending and circumflex coronary arteries

Comparator

Nonischemic portions of myocardium

Outcome

Tissue content of energy-rich phosphates, glycolytic metabolites, and myocardial enzyme activitiessurrogate

Acute coronary occlusion in dogs causes rapid depletion of energy-rich phosphates in ischemic myocardium and compensatory enzymatic hyperfunction in nonischemic myocardium.

Cite This Study

Braasch et al. (1968) studied this question.

synapsesocial.com/papers/6a1bd675ea84844e355f0db7 https://doi.org/10.1161/01.res.23.3.429

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Bookmark

Early Changes in Energy Metabolism in the Myocardium Following Acute Coronary Artery Occlusion in Anesthetized Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Early Changes in Energy Metabolism in the Myocardium Following Acute Coronary Artery Occlusion in Anesthetized Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider