What is the clinical evidence from this study?

Study design: Other. Population: Myocardial ischaemia (n=24). Intervention: Left anterior descending coronary artery ligation. Primary outcome: Time-course of disappearance of macromolecules and electrolytes (creatine kinase, lactate dehydrogenase, myoglobin, K+, Na+) from ischaemic myocardium.

What does this research mean for the field?

In ischemic myocardium, K+ and K+/Na+ depletion reaches a steady state earlier (by 12 hours) than macromolecular markers, serving as the most reliable indices of ischemia intensity during the early phases of 3 to 6 hours. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1981Cardiovascular Research

Depletion of myocardial creatine kinase, lactate dehydrogenase, myoglobin and K+ after coronary artery ligation in dogs

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Key result

Canine myocardial K+ and K+/Na+ ratios reliably mark early ischemia before plateauing at 12 hours.

n=24

Population

24 dogs (4 groups of 6 dogs each)

Design

Preclinical

Follow-up

Up to 24 hours

Authors

RJR N JohnsonEmory University NSNeville SammelSt. Vincent's Birmingham RNR M NorrisCross-Cutting Cardiology

Discussion

Member takes

Implication

K+ and K+/Na+ ratios may mark early ischemia in canine models; leaves open human validation before any clinical use.

Structured PICO

Population

24 dogs undergoing left anterior descending coronary artery ligation for 3, 6, 12, and 24 hours to assess myocardial ischaemia markers.

Intervention

Left anterior descending coronary artery ligation for 3, 6, 12, and 24 hours

Outcome

Time-course of disappearance of creatine kinase, lactate dehydrogenase, myoglobin, K+, and Na+ from ischaemic myocardiumsurrogate

In a canine model of myocardial ischemia, K+ and K+/Na+ ratios are the most reliable markers for early ischemia (3-6 hours).

Cite This Study

Johnson et al. (1981) studied Myocardial ischaemia (n=24). Left anterior descending coronary artery ligation was evaluated on Time-course of disappearance of macromolecules and electrolytes (creatine kinase, lactate dehydrogenase, myoglobin, K+, Na+) from ischaemic myocardium. In dogs with coronary artery ligation, K+ and K+/Na+ ratios reached a steady state of depletion at 12 hours, making them reliable markers for shorter periods of ischaemia (3-6 hours).

synapsesocial.com/papers/6aa4fd9cc19a1092ac8125ce https://doi.org/10.1093/cvr/15.9.529

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September 1, 1981Cardiovascular Research

Depletion of myocardial creatine kinase, lactate dehydrogenase, myoglobin and K+ after coronary artery ligation in dogs

View Full Paper

Ask AI

Bookmark

Key result

Canine myocardial K+ and K+/Na+ ratios reliably mark early ischemia before plateauing at 12 hours.

n=24

Population

24 dogs (4 groups of 6 dogs each)

Design

Preclinical

Follow-up

Up to 24 hours

Authors

RJR N JohnsonEmory University NSNeville SammelSt. Vincent's Birmingham RNR M NorrisCross-Cutting Cardiology

Discussion

Member takes

Implication

K+ and K+/Na+ ratios may mark early ischemia in canine models; leaves open human validation before any clinical use.

Structured PICO

Population

24 dogs undergoing left anterior descending coronary artery ligation for 3, 6, 12, and 24 hours to assess myocardial ischaemia markers.

Intervention

Left anterior descending coronary artery ligation for 3, 6, 12, and 24 hours

Outcome

Time-course of disappearance of creatine kinase, lactate dehydrogenase, myoglobin, K+, and Na+ from ischaemic myocardiumsurrogate

In a canine model of myocardial ischemia, K+ and K+/Na+ ratios are the most reliable markers for early ischemia (3-6 hours).

Cite This Study

synapsesocial.com/papers/6aa4fd9cc19a1092ac8125ce https://doi.org/10.1093/cvr/15.9.529

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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