October 1, 1981AJP Heart and Circulatory Physiology
Prolonged abnormalities of myocardium salvaged by reperfusion
Population
Anesthetized dogs
Comparison
15 min of occlusion of the left anterior… vs Nonischemic subendocardium and preocclusion…
Design
Preclinical
Follow-up
3 days
Authors
Discussion
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Implication
Prolonged stunning without necrosis in animal models may explain delayed recovery; leaves open human translation and clinical monitoring needs.
Structured PICO
P
Population
Anesthetized dogs
I
Intervention
15 min of occlusion of the left anterior descending (LAD) coronary artery followed by 3 days of reperfusion
C
Comparator
Nonischemic subendocardium and preocclusion baseline
O
Outcome
Myocardial ATP and creatine phosphate (CP) concentrations, regional function (percent systolic shortening), and histological/ultrastructural examinationsurrogate
Brief periods of myocardial ischemia without necrosis result in prolonged functional, biochemical, and ultrastructural abnormalities lasting at least 3 days after reperfusion, characteristic of myocardial stunning.
Cite This Study
Kloner et al. (1981) studied this question.