Recovery of regional contractile function and oxidative metabolism in stunned myocardium induced by 1-hour circumflex coronary artery stenosis in chronically instrumented dogs.
Population
27 chronically instrumented dogs
Comparison
1-hour period of myocardial ischemia produced by… vs Normal myocardial zones and baseline control…
Design
Preclinical
Follow-up
up to 2 weeks
Authors
Discussion
Loading...
Member takes
Implication
Reversible post-reperfusion dysfunction in canines supports stunned myocardium concept; leaves open translation to human metabolic recovery timelines.
Structured PICO
P
Population
27 chronically instrumented dogs
I
Intervention
1-hour period of myocardial ischemia produced by graded left circumflex coronary artery stenosis followed by full reperfusion
C
Comparator
Normal myocardial zones and baseline control condition
O
Outcome
Recovery of regional mechanical function (systolic wall thickening) and overall oxidative and fatty acid metabolism measured by positron emission tomography (PET)surrogate
In a canine model, 1-hour coronary stenosis followed by reperfusion causes prolonged but reversible mechanical and metabolic dysfunction (stunned myocardium) that recovers over 1 week.
Cite This Study
Heyndrickx et al. (1993) studied this question.