Why the study?
Does occlusion of the left anterior descending coronary artery alter regional blood flow, contractility, and metabolism in the dog heart?
Population
Dog heart model of early myocardial infarction
Comparison
Occlusion of the left anterior descending… vs Noninfarcted areas of the dog heart
Design
Preclinical
Follow-up
1 and 3 hours
Authors
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Rapid ischemic changes in canine myocardium warrant caution in extrapolating timelines; leaves open relevance to human acute coronary syndromes.
Does occlusion of the left anterior descending coronary artery alter regional blood flow, contractility, and metabolism in the dog heart?
Early myocardial ischemia in a dog model leads to rapid and significant reductions in regional blood flow, mitochondrial respiration, glycolysis, and contractility within 1 to 3 hours.
Weishaar et al. (2008) studied this question.
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