Key result
Preliminary infusion of glucose and insulin in potassium-arrested dog hearts resulted in glycogen consumption at 60 to 100% of the expected rate for 60 minutes in both groups.
Why the study?
Does preliminary infusion of glucose and insulin alter glycogen content, rate of glycolysis, and lactic acid accumulation in potassium-arrested dog hearts?
Population
potassium-arrested hearts excised from dogs
Comparison
preliminary infusion of glucose and insulin vs no preliminary infusion of glucose and insulin
Design
Preclinical
Follow-up
2 hours
Authors
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Findings in arrested canine hearts warrant caution before clinical translation; leaves open whether glucose-insulin infusion improves myocardial protection in surgery.
Does preliminary infusion of glucose and insulin alter glycogen content, rate of glycolysis, and lactic acid accumulation in potassium-arrested dog hearts?
In potassium-arrested dog hearts, glycogen consumption slows significantly after 60 minutes, likely due to lactic acid accumulation, and reperfusion after 90 minutes reveals microcirculatory damage.
Conn et al. (1959) studied potassium-arrested hearts. preliminary infusion of glucose and insulin vs. no preliminary infusion was evaluated on glycogen consumption. Preliminary infusion of glucose and insulin in potassium-arrested dog hearts resulted in glycogen consumption at 60 to 100% of the expected rate for 60 minutes in both groups.
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