Why the study?
Does coronary ligation affect glycogenolysis and glycolysis differently in endocardial versus epicardial layers of the canine left ventricle?
Population
Canine left ventricle model
Comparison
Ligation of a small branch of the left… vs Nonischemic state (baseline)
Design
Preclinical
Authors
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Hypothesis-generating for transmural ischemic vulnerability; leaves open translation to human coronary disease.
Does coronary ligation affect glycogenolysis and glycolysis differently in endocardial versus epicardial layers of the canine left ventricle?
Ischemia accelerates glycogenolysis and glycolysis more rapidly and markedly in the endocardial layers than in the epicardial layers of the canine heart.
Ichihara et al. (1975) studied this question.
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