December 1, 1982Circulation Research

A neural factor involved in increase of the glycogen phosphorylase activity after coronary ligation in both ischemic and nonischemic areas of the dog heart.

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Why the study?

Does coronary artery ligation increase glycogen phosphorylase activity via extracardiac neural factors in dog hearts?

Population

Dog models of acute myocardial ischemia (in vivo, heart-lung preparation, and stellectomized dogs)

Comparison

Ligation of a branch of the left anterior… vs Pretreatment with reserpine, hexamethonium…

Design

Preclinical

Follow-up

1.5 minutes

Authors

KSKenji SakaiDoshisha University YAYasushi AbikoAsahikawa Medical College Hospital

Discussion

Member takes

Implication

Hypothesis-generating for sympathetic neural control of myocardial metabolism in ischemia; leaves open translation to human acute coronary syndromes.

Structured PICO

Does coronary artery ligation increase glycogen phosphorylase activity via extracardiac neural factors in dog hearts?

Population

Dog models of acute myocardial ischemia (in vivo, heart-lung preparation, and stellectomized dogs)

Intervention

Ligation of a branch of the left anterior descending coronary artery (LAD) for 1.5 minutes

Comparator

Pretreatment with reserpine (1 mg/kg im), hexamethonium (3 mg/kg iv), adrenalectomy, stellectomy, or heart-lung preparation

Outcome

Glycogen phosphorylase activity in the endocardial and epicardial layers of ischemic and nonischemic areassurrogate

Acute coronary ligation increases glycogen phosphorylase activity globally in the heart, a response mediated by efferent cardiac sympathetic nerve activity rather than circulating catecholamines.

Cite This Study

Sakai et al. (1982) studied this question.

synapsesocial.com/papers/6a86f130a810ea404bcf96ec https://doi.org/10.1161/01.res.51.6.733

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Implication

Hypothesis-generating for sympathetic neural control of myocardial metabolism in ischemia; leaves open translation to human acute coronary syndromes.

A neural factor involved in increase of the glycogen phosphorylase activity after coronary ligation in both ischemic and nonischemic areas of the dog heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A neural factor involved in increase of the glycogen phosphorylase activity after coronary ligation in both ischemic and nonischemic areas of the dog heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider