Relationship between Epicardial S-T Segment Changes and Myocardial Metabolism during Acute Coronary Insufficiency
Population
Canine model of acute coronary insufficiency
Comparison
Ligation of the left anterior descending… vs Isoelectric sites (internal comparison)
Design
Preclinical
Follow-up
17 minutes
Authors
Discussion
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Member takes
Implication
ST elevation marks severe local ischemia in acute canine models; leaves open human applicability and prospective validation.
Structured PICO
P
Population
Canine model of acute coronary insufficiency
I
Intervention
Ligation of the left anterior descending coronary artery at its midlevel for 17 minutes
C
Comparator
Isoelectric sites (internal comparison)
O
Outcome
Relationship between epicardial S-T segment changes and myocardial metabolism (ATP, creatine phosphate, glycogen, glucose, glucose-6-phosphate, and lactate)surrogate
Epicardial S-T segment elevation during acute ischemia correlates with pronounced local anaerobic metabolism and depletion of high-energy phosphates in a canine model.
Cite This Study
Karlsson et al. (1973) studied this question.