Key result
Acute regional ischemia decreased tissue carnitine and ATP levels, which were significantly lower in the subendocardium than the subepicardium, confirming greater anaerobic metabolism in the subendocardium.
Population
31 mongrel dogs weighing 8 to 15 kg (21 normal and 10 experimental infarction)
Comparison
Acute regional ischemia induced by ligation of… vs Normal dog hearts and nonischemic areas
Design
Preclinical
Follow-up
15 min
Authors
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Hypothesis-generating for subendocardial protection; should not yet change clinical practice.
The subendocardium is metabolically more anaerobic than the subepicardium in normal dog hearts, and this difference becomes more prominent during acute regional ischemia.
Suzuki et al. (1981) studied Acute regional myocardial ischemia (n=31). Acute regional ischemia (coronary artery ligation) vs. Normal hearts and nonischemic areas was evaluated on Tissue levels of carnitine, ATP, and free fatty acids in subepicardial and subendocardial regions. Acute regional ischemia decreased tissue carnitine and ATP levels, which were significantly lower in the subendocardium than the subepicardium, confirming greater anaerobic metabolism in the subendocardium.
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