August 1, 2000Shock
Lactate Improves Cardiac Efficiency After Hemorrhagic Shock
Key result
Adding 8.0 mM lactate improves cardiac work and efficiency in shocked rat hearts.
Why the study?
The role of lactate on cardiac function and metabolism after severe acute hemorrhagic shock was not well understood.
Does lactate improve cardiac efficiency in isolated rat hearts after severe acute hemorrhagic shock?
Population
Anesthetized, nonheparinized rats subjected to severe acute hemorrhagic shock and unbled controls
Comparison
Hearts perfused with glucose + palmitate with or without 8.0 mM lactate
Design
Preclinical isolated working heart study
Follow-up
60 min
Authors
Discussion
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Implication
Lactate may enhance efficiency in this model; hypothesis-generating and should not change shock management.
Structured PICO
Does lactate improve cardiac efficiency in isolated rat hearts after severe acute hemorrhagic shock?
P
Population
Anesthetized, nonheparinized rats subjected to severe acute hemorrhagic shock to examine the role of lactate on cardiac function and metabolism.
I
Intervention
Perfusion of isolated working hearts with 8.0 mM lactate added to glucose + palmitate (0.4 mM or 1.2 mM).
C
Comparator
Perfusion with glucose alone, or glucose + palmitate without lactate.
O
Outcome
Cardiac work and efficiency (work/oxygen consumption) measured in isolated working heart mode for 60 min.surrogate
In a rat model of severe hemorrhagic shock, lactate improves cardiac efficiency in the presence of free fatty acids, possibly by anaplerosis of the tricarboxylic acid cycle.
Cite This Study
Kline et al. (2000) studied Severe acute hemorrhagic shock. Lactate vs. Perfusion without lactate was evaluated on Cardiac work and efficiency. The addition of 8.0 mM lactate significantly improved cardiac work and efficiency in shocked rat hearts perfused with free fatty acids.