Population
Isolated rat hearts (n = 6/group)
Comparison
Langendorff perfusion with media at high lactate… vs Langendorff perfusion with media at normal…
Design
Preclinical
Authors
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Should not yet change ischemia management; leaves open distinct lactate versus acidosis mechanisms in human myocardium.
In isolated rat hearts, high lactate causes irreversible myocardial contractility depression, whereas high H+ causes reversible depression, suggesting different mechanisms of myocardial impairment during ischemia or heavy exercise.
Samaja et al. (1999) studied this question.
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