Key result
Lowering pH depresses pacemaker and ventricular function in anoxic rat hearts by affecting energy utilization.
Why the study?
Does increased extracellular hydrogen ion concentration (acidosis) affect the performance and anaerobic metabolism of the anoxic isolated rat heart?
Population
Isolated rat heart perfused at constant rate (10 ml per minute) with 5% albumin in KRB
Comparison
Increased extracellular H+ ion concentration to… vs Anoxia at pH 7.4
Design
Preclinical
Follow-up
30 minutes
Authors
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Acidosis effects on anoxic rat hearts should not change clinical practice; leaves open mechanistic translation to in vivo ischemia or human therapeutics.
Does increased extracellular hydrogen ion concentration (acidosis) affect the performance and anaerobic metabolism of the anoxic isolated rat heart?
In the anoxic isolated rat heart, acidosis to pH 7.0 depresses cardiac function primarily by affecting energy utilization rather than suppressing glycolytic activity, which is only diminished at pH 6.6.
GELET et al. (1969) studied Anoxia. Increased extracellular H+ ion (acidosis) vs. pH 7.4 was evaluated on Cardiac pacemaker activity, left ventricular contractile performance, and anaerobic metabolism. Decreasing the pH of anoxic perfusate to 7.0 or 6.6 significantly depressed cardiac pacemaker activity and ventricular performance in isolated rat hearts, primarily affecting energy utilization.
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