Key result
In isolated perfused rat hearts, Krebs cycle activity was unaltered by pH changes from 7.1 to 8.0 despite decreased mechanical activity at pH 7.1, while glycolysis and acetate oxidation increased above pH 7.4.
Why the study?
Does varying extracellular pH affect mechanical function and metabolism in isolated perfused rat hearts?
Population
Isolated perfused rat hearts
Comparison
Extracellular pH variation from 6.9 to 8.0 vs pH 7.4
Design
Preclinical
Authors
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Should not inform clinical pH targets; extends isolated-heart metabolic data but leaves open human translation.
Does varying extracellular pH affect mechanical function and metabolism in isolated perfused rat hearts?
In isolated rat hearts, acidosis (pH 7.1) depresses mechanical function without altering Krebs cycle activity, while alkalosis (pH 8.0) stimulates glycolysis and acetate oxidation.
Lionel H. Opie (1965) studied Isolated perfused rat heart. Extracellular pH variation vs. pH 7.4 was evaluated on Isovolumic left ventricular contractility and metabolism. In isolated perfused rat hearts, Krebs cycle activity was unaltered by pH changes from 7.1 to 8.0 despite decreased mechanical activity at pH 7.1, while glycolysis and acetate oxidation increased above pH 7.4.
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