In perfused rabbit and rat septa, respiratory acidosis causes a significant loss of tension and a net uptake of K+ dependent on depolarization, suggesting contractility and K+ uptake are controlled by intracellular H+ concentration.
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Respiratory acidosis may impair myocardial tension and promote K+ uptake in animal septa; hypothesis-generating and should not change clinical practice.
Poole-Wilson et al. (1975) studied this question.
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