Key result
Decreasing the pH of the bathing medium from 7.5 to 6.1 in isolated rabbit atrial muscle increased extracellular K+ activity from a control level of 3.6 mM to 4.9 mM.
Absolute Event Rate: 4.9% vs 3.6%
Acidosis in rabbit atrial muscle causes a reversible efflux of intracellular potassium, increasing extracellular potassium and altering action potential characteristics.
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May link acidosis to atrial K+ shifts and arrhythmias in models; leaves open human relevance.
Skinner et al. (1976) studied Isolated superfused rabbit atrial muscle. Decreased pH vs. Normal pH (7.5) was evaluated on Extracellular potassium (K+) activity. Decreasing the pH of the bathing medium from 7.5 to 6.1 in isolated rabbit atrial muscle increased extracellular K+ activity from a control level of 3.6 mM to 4.9 mM.
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