November 1, 1975Circulation ResearchOpen Access

Influence of potassium ions and osmolality on the resting membrane potential of rabbit ventricular papillary muscle with estimation of the activity and the activity coefficient of internal potassium.

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Population

Rabbit right ventricular papillary muscles

Comparison

Modified Tyrode's solutions that were hypertonic… vs Isotonic Tyrode's solution (1.0 X T)

Design

Preclinical

Authors

TAT AkiyamaOrgan Technologies (Japan)HFHarry A. FozzardUniversity of Vermont

Discussion

Member takes

Implication

Challenges perfect osmometer predictions in hypertonic rabbit papillary muscle; extends basic cardiac physiology but leaves open clinical translation.

Structured PICO

Population

Rabbit right ventricular papillary muscles

Intervention

Modified Tyrode's solutions that were hypertonic (1.58 X T) or hypotonic (0.76 X T) at eight different concentrations of external potassium (0.78 to 100 mM)

Comparator

Isotonic Tyrode's solution (1.0 X T)

Outcome

Resting membrane potential and estimated activity/activity coefficient of intracellular potassiumsurrogate

The study demonstrates that changes in resting membrane potential of rabbit papillary muscles in hypertonic solutions deviate from perfect osmometer predictions, likely due to a decrease in the activity coefficient of intracellular potassium.

Cite This Study

Akiyama et al. (1975) studied this question.

synapsesocial.com/papers/6a7c3137487e1f6bb31f6e53 https://doi.org/10.1161/01.res.37.5.621

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Implication

Challenges perfect osmometer predictions in hypertonic rabbit papillary muscle; extends basic cardiac physiology but leaves open clinical translation.