Population
Rabbit ventricular muscle
Comparison
Exposure to various extracellular K… vs Control conditions
Design
Preclinical
Authors
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Warrants no change in clinical practice; leaves open whether electrogenic Na extrusion modulates human ventricular potential in hypokalemia.
This preclinical study demonstrates that electrogenic sodium extrusion contributes significantly to the resting potential in rabbit ventricular muscle, suggesting independent control mechanisms for the Na-K coupling ratio and pumping rate.
Ruiz-Ceretti et al. (1981) studied this question.
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