Why the study?
Does decreasing extracellular potassium induce transient depolarizations and action potentials in isolated rabbit ventricular myocytes?
Population
Isolated rabbit ventricular myocytes (n=127)
Comparison
Decreasing extracellular potassium to 0.1 mM vs Normal extracellular potassium level of 5.4 mM
Design
Preclinical
Authors
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Extreme hypokalemia may trigger APs via hyperpolarization in rabbit myocytes; hypothesis-generating for arrhythmogenesis and requires in vivo/human validation.
Does decreasing extracellular potassium induce transient depolarizations and action potentials in isolated rabbit ventricular myocytes?
Severe hypokalemia induces hyperpolarization that triggers transient depolarizations and action potentials in rabbit ventricular myocytes, likely due to electroporation from strong electric fields.
Akuzawa-Tateyama et al. (1998) studied this question.
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