Population
Freshly isolated rabbit ventricular myocytes
Comparison
Raising intracellular Ca2+ from 100 to 600 nM… vs Lower [Ca2+]i or absence of beta-AR stimulation
Design
Preclinical
Authors
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Supports Ca2+-dependent IKs modulation in rabbit myocytes; hypothesis-generating for human ventricular repolarization.
Physiological intracellular Ca2+ levels (500-600 nM) are sufficient to maximize Ca2+-dependent IKs activation during normal action potentials in rabbit ventricular myocytes.
Bartos et al. (2016) studied this question.
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