Population
Rabbit isolated sino-atrial node (SAN) pacemaker cells
Comparison
Block of iKs by 293b with or without… vs Control conditions
Design
Preclinical
Authors
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iKs may regulate rabbit SAN rate during beta-stimulation; leaves open translation to human arrhythmia mechanisms.
In rabbit sino-atrial node cells, the iKs current plays a significant role in regulating pacemaker rate during beta-adrenergic stimulation, but has minimal effect under baseline conditions.
Ming Lei (2002) studied this question.
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