Population
Myocytes dissociated from the sinoatrial node of rat heart showing regular rhythmic contractions and…
Design
Preclinical
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Ist characterization in rat SAN cells extends pacemaker current knowledge; leaves open human translation and therapeutic relevance.
This study characterizes the sustained inward current (Ist) and inward rectifier K+ current in rat sinoatrial node pacemaker cells, demonstrating that Ist provides a positive feedback loop during diastolic depolarization.
Shinagawa et al. (2000) studied this question.
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