January 1, 1997The Japanese Journal of PhysiologyOpen Access

Existence of a Low-Threshold and Sustained Inward Current in Rabbit Atrio-Ventricular Node Cells.

View Full Paper

Ask AI

Bookmark

Population

Single myocytes dissociated from the atrio-ventricular (AV) node of rabbit hearts

Comparison

Whole-cell voltage clamp with depolarizing… vs Control conditions

Design

Preclinical

Authors

JGJiqing GuoLibin Cardiovascular Institute of Alberta ANAkinori NomaElectrophysiology

Discussion

Member takes

Implication

Ist in rabbit AV node cells leaves open human relevance; hypothesis-generating for pacemaker mechanisms.

Structured PICO

Population

Single myocytes dissociated from the atrio-ventricular (AV) node of rabbit hearts

Intervention

Whole-cell voltage clamp with depolarizing pulses from -80 mV, application of nicardipine, verapamil, reducing [Ca2+]o, and depleting [Na+]o

Comparator

Control conditions (e.g., before applying blockers or changing ion concentrations)

Outcome

Presence and characteristics of a sustained inward current (activation threshold, maximum amplitude, sensitivity to blockers and ion concentrations)surrogate

Identifies a low-threshold, sustained inward current (Ist) in rabbit AV node fusiform cells, contributing to our understanding of cardiac pacemaker electrophysiology.

Cite This Study

Guo et al. (1997) studied this question.

synapsesocial.com/papers/6a701ee55d37378ac1dd2ef0 https://doi.org/10.2170/jjphysiol.47.355

View Full Paper

Ask AI

Bookmark

Existence of a Low-Threshold and Sustained Inward Current in Rabbit Atrio-Ventricular Node Cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Existence of a Low-Threshold and Sustained Inward Current in Rabbit Atrio-Ventricular Node Cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider