Population
Rabbit sinoatrial node cells
Design
Preclinical
Authors
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IK,r blockade may disrupt SAN automaticity in vitro; leaves open in vivo effects on heart rate.
The rapidly activating delayed rectifier K+ current (IK,r) plays an essential role in determining the maximum diastolic potential and ensuring the firing of subsequent action potentials in sinoatrial node cells.
Kyoichi Ono (1995) studied this question.
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