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June 1, 1994AJP Cell Physiology

Physiological role of Ca(2+)-activated and voltage-dependent K+ currents in rabbit coronary myocytes

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Population

Rabbit coronary myocytes

Comparison

Pharmacological inhibition and elevation of… vs Baseline/steady-state conditions

Design

Preclinical

Authors

NLNormand LeblancUniversity of Nevada, RenoXWXiaoyang WanBaylor College of MedicinePLPhilip M.B. LeungLeeds General Infirmary

Discussion

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Overview

Does not inform clinical coronary vasoregulation; extends rabbit myocyte ion channel models while leaving human translation open.

Structured PICO

P
Population
Rabbit coronary myocytes
I
Intervention
Pharmacological inhibition (tetraethylammonium chloride, charybdotoxin, nifedipine, 4-aminopyridine) and elevation of extracellular Ca2+ concentration
C
Comparator
Baseline/steady-state conditions
O
Outcome
Electrophysiological properties including current-voltage relations and resting membrane potential (Enet)surrogate

In rabbit coronary myocytes, voltage-dependent K+ and L-type Ca2+ currents primarily regulate resting membrane potential, while Ca2+-activated K+ currents provide a feedback mechanism to limit Ca2+ entry during intracellular Ca2+ elevation.

Cite This Study

Leblanc et al. (1994) studied this question.

synapsesocial.com/papers/6a70dcd58031ec7bb1dca268https://doi.org/10.1152/ajpcell.1994.266.6.c1523
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium currents in isolated rabbit coronary arterial smooth muscle myocytes.1990 · 83 citations
  2. 2Two components of potassium current activated by depolarization of single smooth muscle cells from the rabbit portal vein.1989 · 169 citations
  3. 3Macroscopic K+ currents in single smooth muscle cells of the rabbit portal vein.1989 · 89 citations
  4. 4Outward potassium currents in freshly isolated smooth muscle cell of dog coronary arteries.1989 · 32 citations
  5. 5Ionic currents in single smooth muscle cells of the canine renal artery.1992 · 80 citations