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July 1, 1991The Journal of PhysiologyOpen Access

A voltage‐dependent potassium current in rabbit coronary artery smooth muscle cells.

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Population

Enzymatically isolated smooth muscle cells from the rabbit left descending coronary artery, as well as…

Design

Preclinical

Authors

KVKenneth A. VolkUniversity of IowaJMJames J. MatsudaUniversity of IowaESE F ShibataUniversity of Iowa

Discussion

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Implication

Identifies a TEA/4-AP-resistant delayed rectifier K+ current in animal coronary myocytes; leaves open its role in human vasoregulation and therapeutic targeting.

Structured PICO

P
Population
Enzymatically isolated smooth muscle cells from the rabbit left descending coronary artery, as well as guinea-pig and human coronary artery myocytes.
I
Intervention
Single pipette voltage clamp technique and application of potassium channel blockers (TEA, 4-AP).
O
Outcome
Electrophysiological characteristics of voltage- and time-dependent outward potassium currents (kinetics, voltage-dependence, and pharmacological blockade).surrogate

This preclinical study characterizes a delayed rectifier-like voltage-dependent potassium current in coronary artery smooth muscle cells, detailing its kinetics and pharmacological profile.

Cite This Study

Volk et al. (1991) studied this question.

synapsesocial.com/papers/6a71504435aa2c282ce29ecchttps://doi.org/10.1113/jphysiol.1991.sp018691
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Also Consider

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  2. 2Two components of potassium current activated by depolarization of single smooth muscle cells from the rabbit portal vein.1989 · 169 citations
  3. 3Calcium currents in isolated rabbit coronary arterial smooth muscle myocytes.1990 · 83 citations
  4. 4A voltage‐dependent outward current with fast kinetics in single smooth muscle cells isolated from rabbit portal vein.1989 · 87 citations
  5. 5Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres1969 · 459 citations