Key result
Outward current evoked by depolarization in rabbit portal vein smooth muscle cells is carried by 100 pS Ca2+-activated K+ channels and by small-conductance (5 pS) delayed-rectifier K+ channels.
Population
Single smooth muscle cells enzymatically isolated from the rabbit portal vein
Design
Preclinical
Authors
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Extends K+ channel mapping in animal vascular smooth muscle; leaves open translation to human vasoregulation or therapy.
Depolarization-evoked outward currents in rabbit portal vein smooth muscle cells are carried by both small-conductance delayed-rectifier K+ channels and large-conductance Ca2+-activated K+ channels.
Beech et al. (1989) studied Rabbit portal vein smooth muscle cells. Patch-clamp technique and K+ channel blockers was evaluated on Characterization of outward K+ currents. Outward current evoked by depolarization in rabbit portal vein smooth muscle cells is carried by 100 pS Ca2+-activated K+ channels and by small-conductance (5 pS) delayed-rectifier K+ channels.
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