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October 1, 1992Circulation Research

Ionic currents in single smooth muscle cells of the canine renal artery.

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Population

Single smooth muscle cells enzymatically isolated from canine renal artery

Design

Preclinical

Authors

CGCraig H. GelbandJHJoseph R. Hume

Discussion

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Overview

Should not change clinical practice; leaves open translation of canine renal artery channel properties to human disease.

Structured PICO

P
Population
Single smooth muscle cells enzymatically isolated from canine renal artery
I
Intervention
Electrophysiological characterization using patch-clamp technique and pharmacological agents (e.g., Bay K 8644, nisoldipine, NiCl2, CdCl2, EGTA, tetraethylammonium, charybdotoxin, 4-aminopyridine)
O
Outcome
Identification and characterization of membrane ionic currents (inward Ca2+ and outward K+ currents)surrogate

This basic science study characterizes the electrophysiological properties of canine renal artery smooth muscle cells, identifying specific dihydropyridine-sensitive Ca2+ channels and two distinct K+ channels.

Cite This Study

Gelband et al. (1992) studied this question.

synapsesocial.com/papers/6a7ac320b2ad017e4032315ehttps://doi.org/10.1161/01.res.71.4.745
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outward potassium currents in freshly isolated smooth muscle cell of dog coronary arteries.1989 · 32 citations
  2. 2Potassium currents in canine airway smooth muscle cells1990 · 46 citations
  3. 3Calcium and potassium currents in canine gastric smooth muscle cells1992 · 24 citations
  4. 4Two components of potassium current activated by depolarization of single smooth muscle cells from the rabbit portal vein.1989 · 169 citations
  5. 5Calcium-sensitive potassium current in isolated canine coronary smooth muscle cells1994 · 8 citations