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December 1, 1990AJP Lung Cellular and Molecular Physiology

Potassium currents in canine airway smooth muscle cells

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Population

Dissociated canine tracheal smooth muscle cells

Comparison

Whole cell patch-clamp technique with various… vs Baseline/control conditions

Design

Preclinical

Authors

MKMichael I. KotlikoffElectrophysiology

Discussion

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Overview

Extends ion channel mapping in canine airway myocytes; hypothesis-generating for human respiratory physiology with no immediate clinical implications.

Structured PICO

P
Population
Dissociated canine tracheal smooth muscle cells
I
Intervention
Whole cell patch-clamp technique with various ion substitutions and pharmacological agents (Cs+, TEA+, Mn2+, nifedipine, Ba2+, charybdotoxin, methacholine, A23187)
C
Comparator
Baseline/control conditions (e.g., normal bath solution, different EGTA concentrations)
O
Outcome
Electrical properties, specifically outward K+ currents (delayed rectifier and Ca2+-activated K+ currents)surrogate

This preclinical study characterizes the specific potassium channels responsible for membrane rectification and calcium-activated responses in canine airway smooth muscle cells.

Cite This Study

Michael I. Kotlikoff (1990) studied this question.

synapsesocial.com/papers/6a87368237e82e140d1548dahttps://doi.org/10.1152/ajplung.1990.259.6.l384
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium‐activated potassium channels in canine airway smooth muscle.1986 · 160 citations
  2. 2Calcium and potassium currents in canine gastric smooth muscle cells1992 · 24 citations
  3. 3Effects of tetraethylammonium and 4‐aminopyridine on outward currents and excitability in canine tracheal smooth muscle cells1990 · 64 citations
  4. 4Outward potassium currents in freshly isolated smooth muscle cell of dog coronary arteries.1989 · 32 citations
  5. 5Ionic currents in single smooth muscle cells of the canine renal artery.1992 · 80 citations