Calcium‐activated potassium channels in canine airway smooth muscle.
Population
Airway smooth muscle cells dispersed from canine trachealis muscle
Comparison
Patch-clamp technique with varying membrane… vs Baseline conditions
Design
Preclinical
Authors
Discussion
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Overview
Characterizes KCa channels in canine airway myocytes; leaves open their role in human bronchomotor control.
Structured PICO
P
Population
Airway smooth muscle cells dispersed from canine trachealis muscle
I
Intervention
Patch-clamp technique with varying membrane potentials, cytoplasmic calcium concentrations (10(-8) to 10(-6) M), and channel blockers (tetraethylammonium, tetramethylammonium, Cs, Ba)
C
Comparator
Baseline conditions (lower calcium concentrations, absence of blockers)
O
Outcome
Single channel currents and conductancesurrogate
This study characterizes the electrophysiological properties of calcium-activated potassium channels in canine airway smooth muscle cells, demonstrating their voltage and calcium dependence.
Cite This Study
McCann et al. (1986) studied this question.