Key result
A lower conductance delayed rectifier potassium channel (12.7 pS) was identified in canine and porcine airway smooth muscle cells, which was insensitive to calcium and blocked by 4-aminopyridine.
Population
Canine and porcine trachealis cells (airway smooth muscle cells)
Design
Preclinical
Authors
Loading...
Extends ion channel mapping in large-animal ASM; leaves open human airway disease relevance and therapeutic targeting.
The study characterizes a calcium-insensitive, delayed rectifier potassium channel in canine and porcine airway smooth muscle cells that is sensitive to 4-aminopyridine.
Boyle et al. (1992) studied Basic science (airway smooth muscle cells). Electrophysiological recording was evaluated on Unitary potassium currents. A lower conductance delayed rectifier potassium channel (12.7 pS) was identified in canine and porcine airway smooth muscle cells, which was insensitive to calcium and blocked by 4-aminopyridine.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: