Key result
The delayed rectifier K+ current in canine colonic smooth muscle consists of three distinct components (IdK(f), IdK(s), and IdK(n)) with differing kinetics and sensitivities to TEA and 4-AP.
Population
canine colonic myocytes
Comparison
TEA and 4-aminopyridine vs control conditions
Design
Preclinical
Authors
Loading...
No immediate clinical implications for motility disorders; leaves open distinct molecular identities of IdK components.
The delayed rectifier K+ current in canine colonic smooth muscle consists of three distinct components with unique kinetic and pharmacological profiles.
A. Carl (1995) studied Canine colonic smooth muscle electrophysiology. Tetraethylammonium (TEA) and 4-aminopyridine (4-AP) vs. Control conditions was evaluated on Delayed rectifier K+ current (IdK) block and activation kinetics. The delayed rectifier K+ current in canine colonic smooth muscle consists of three distinct components (IdK(f), IdK(s), and IdK(n)) with differing kinetics and sensitivities to TEA and 4-AP.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: