Key result
TEA-sensitive delayed rectifier currents determine action potential amplitude, whereas 4-AP-sensitive currents determine rhythmicity in murine colonic smooth muscle.
Population
Murine colonic smooth muscle (intact tissue and isolated myocytes)
Comparison
Tetraethylammonium and 4-Aminopyridine vs Baseline/control conditions
Design
Preclinical
Authors
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Murine colonic spike characterization with K+ blockers; leaves open translation to human motility disorders.
This preclinical study identifies distinct roles for TEA-sensitive and 4-AP-sensitive delayed rectifier potassium currents in regulating the electrical activity of murine colonic smooth muscle.
Koh et al. (1999) studied this question. Tetraethylammonium (TEA) and 4-Aminopyridine (4-AP) was evaluated on Membrane potential, action potential amplitude, and rhythmicity. TEA-sensitive delayed rectifier currents determine action potential amplitude, whereas 4-AP-sensitive currents determine rhythmicity in murine colonic smooth muscle.
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