This preclinical study demonstrates that a Ba2+-sensitive inward rectifier potassium conductance, likely Kir2.1, regulates the resting membrane potential in interstitial cells of Cajal of the canine colon.
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Hypothesis-generating for ICC pacemaker function in motility disorders; leaves open Kir2.1 targeting pending human validation.
Flynn et al. (1999) studied this question.
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