Key result
Canine gastric corpus smooth muscle cells possess K+ and L-type Ca2+ channels, with the Ca2+ current showing transient and sustained components and a half-inactivation potential of roughly -37 mV.
Population
Single smooth muscle cells dissociated from circular muscle of dog stomach (corpus region)
Design
Preclinical
Authors
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Should not change clinical practice in gastric disorders; leaves open translational studies of these channels in human GI smooth muscle.
Canine gastric corpus smooth muscle cells possess K+ and Ca2+ channels, predominantly L-type Ca2+ channels.
Stephen M. Sims (1992) studied Canine gastric smooth muscle cells. Voltage clamp and ion channel blockers was evaluated on Membrane ionic currents (K+ and Ca2+). Canine gastric corpus smooth muscle cells possess K+ and L-type Ca2+ channels, with the Ca2+ current showing transient and sustained components and a half-inactivation potential of roughly -37 mV.
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