Population
Freshly dispersed smooth muscle cells from the circular layer of the canine proximal colon
Comparison
Nifedipine (10^-6 M) and BAY K 8644 (1 microM) vs Baseline conditions without drug
Design
Preclinical
Authors
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May inform dihydropyridine effects on GI motility; hypothesis-generating for uniform C-class Ca channels in smooth muscle, pending human studies.
Inward calcium currents in canine colonic smooth muscle cells are regulated by a single class of dihydropyridine-sensitive calcium channels.
Rich et al. (1993) studied this question.
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