Key result
The upstroke and plateau components of canine colonic slow waves depend on voltage-dependent Ca2+ currents, with the upstroke partially resistant to dihydropyridines and the plateau nifedipine-sensitive.
Population
Canine colonic circular muscles
Design
Preclinical
Authors
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Extends Ca2+ dependence of canine colonic slow waves; human motility relevance remains untested.
The upstroke and plateau components of slow waves in canine colonic smooth muscle depend on voltage-dependent Ca2+ currents with differing sensitivities to dihydropyridines and inorganic blockers.
Ward et al. (1992) studied Canine colonic smooth muscle physiology. Reduced extracellular Ca2+ and calcium channel blockers (Nifedipine, Mn2+, Ni2+) was evaluated on Amplitude and velocity of upstroke and plateau components of slow waves. The upstroke and plateau components of canine colonic slow waves depend on voltage-dependent Ca2+ currents, with the upstroke partially resistant to dihydropyridines and the plateau nifedipine-sensitive.
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