October 1, 1991The Journal of PhysiologyOpen Access

Generation of slow‐wave‐type action potentials in canine colon smooth muscle involves a non‐L‐type Ca2+ conductance.

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Population

Canine colon smooth muscle

Comparison

Ion substitutions and channel blockers vs Normal conditions or varying concentrations of…

Design

Preclinical

Authors

JHJan D. HuizingaDigestive Health Research Institute LFLaura FarrawayMcMaster University AHA. den HertogLeiden University

Discussion

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Implication

Non-L-type Ca2+ entry may initiate colonic slow waves in canines; leaves open molecular targets and human relevance for GI motility research.

Structured PICO

Population

Canine colon smooth muscle

Intervention

Ion substitutions and channel blockers (glucamine-nitrendipine Krebs solution, removal of extracellular calcium, addition of Ni2+, Cd2+, Co2+, Mg2+, Ba2+)

Comparator

Normal conditions or varying concentrations of extracellular ions

Outcome

Rate of rise and amplitude of the upstroke potential of the slow wavesurrogate

The study provides evidence that a non-L-type calcium conductance initiates slow-wave action potentials in canine colonic smooth muscle.

Cite This Study

Huizinga et al. (1991) studied this question.

synapsesocial.com/papers/6a83874546c7ded554a77f87 https://doi.org/10.1113/jphysiol.1991.sp018779

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Implication

Non-L-type Ca2+ entry may initiate colonic slow waves in canines; leaves open molecular targets and human relevance for GI motility research.

Generation of slow‐wave‐type action potentials in canine colon smooth muscle involves a non‐L‐type Ca2+ conductance.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Generation of slow‐wave‐type action potentials in canine colon smooth muscle involves a non‐L‐type Ca2+ conductance.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider