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September 1, 1989The Journal of PhysiologyOpen Access

Ionic basis of pacemaker generation in dog colonic smooth muscle.

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Population

Dog colonic smooth muscle (circular muscle)

Comparison

Various ion channel blockers and ion substitutions vs Baseline/control conditions

Design

Preclinical

Authors

CBCarlos Barajas‐LópezInstitute for Scientific and Technological ResearchAHA. den HertogLeiden UniversityJHJan D. HuizingaDigestive Health Research Institute

Discussion

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Implication

Does not inform clinical GI management; hypothesis-generating for slow-wave mechanisms with translation to humans untested.

Structured PICO

P
Population
Dog colonic smooth muscle (circular muscle)
I
Intervention
Various ion channel blockers and ion substitutions (tetrodotoxin, N-methyl-D-glucamine, isethionate, sucrose, D600, CoCl2, EGTA, Li+ HEPES, high-K+)
C
Comparator
Baseline/control conditions
O
Outcome
Intracellular electrical activity (slow waves, membrane potential)surrogate

In dog colonic smooth muscle, slow waves appear to be initiated by the blockade of a K+ conductance and depend on extracellular Ca2+ and membrane potential.

Cite This Study

Barajas‐López et al. (1989) studied this question.

synapsesocial.com/papers/6a8387d6b397c5df40cd7da2https://doi.org/10.1113/jphysiol.1989.sp017767
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Also Consider

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  1. 1A study of pace‐maker activity in intestinal smooth muscle1974 · 117 citations
  2. 2Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology.1985 · 719 citations
  3. 3Role of sodium pump in membrane potential gradient of canine proximal colon1988 · 21 citations
  4. 4Cable properties of smooth muscle1968 · 398 citations
  5. 5Electrogenic sodium pumping in rabbit small intestinal smooth muscle1975 · 29 citations