Key result
Oscillations in the level of an electrogenic pump current produce slow waves in the longitudinal muscle of cat duodenum.
Population
Longitudinal muscle preparations from cat intestine (duodenum)
Comparison
Electrophysiological manipulations including… vs Baseline/control conditions
Design
Preclinical
Authors
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Preclinical cat data link pump oscillations to duodenal slow waves; leaves open translation to human GI motility.
This preclinical study demonstrates that slow-wave pacemaker activity in cat intestinal smooth muscle is driven by oscillations in an electrogenic pump current.
Connor et al. (1974) studied Intestinal smooth muscle electrophysiology. Electrophysiological manipulations (ouabain, ion replacement, voltage/current clamp) was evaluated on Membrane voltage fluctuations (slow waves) and pump current. Oscillations in the level of an electrogenic pump current produce slow waves in the longitudinal muscle of cat duodenum.
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