Population
Dog colonic smooth muscle (circular muscle)
Comparison
Blockade of the Na+ pump, reduction of… vs Control conditions
Design
Preclinical
Authors
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Challenges Na+ pump targeting in colonic motility; leaves open conductance-based pacemaking for human tissue studies.
Demonstrates that pacemaker activity in colonic smooth muscle is likely a consequence of metabolically dependent membrane conductance changes rather than direct Na+ pump activity.
Barajas‐López et al. (1989) studied this question.
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