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July 1, 1992AJP Cell Physiology

Participation of fast-activating, voltage-dependent K currents in electrical slow waves of colonic circular muscle

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Population

Canine colonic circular muscle cells and intact muscles

Comparison

Depolarization, temperature increase to 37°C… vs Baseline conditions

Design

Preclinical

Authors

KTK. D. ThornburyDundalk Institute of TechnologySWSean M. WardUniversity of Nevada, RenoKSKenton M. SandersElectrophysiology

Discussion

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Implication

Animal data implicate voltage-dependent K currents in colonic slow wave regulation; leaves open translation to human motility disorders.

Structured PICO

P
Population
Canine colonic circular muscle cells and intact muscles
I
Intervention
Depolarization, temperature increase to 37°C, and application of 4-aminopyridine (4-AP; 1-5 mM)
C
Comparator
Baseline conditions (room temperature, absence of 4-AP)
O
Outcome
Characteristics of voltage-dependent outward K+ currents and electrical slow waves (amplitude, rate of rise, plateau phase duration)surrogate

A rapidly activating, inactivating, voltage-dependent K current plays a role in regulating the electrical slow waves of colonic circular smooth muscles.

Cite This Study

Thornbury et al. (1992) studied this question.

synapsesocial.com/papers/6a206d2fddea50bfc43d2067https://doi.org/10.1152/ajpcell.1992.263.1.c226
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ionic basis of pacemaker generation in dog colonic smooth muscle.1989 · 38 citations
  2. 2Characteristics of transient outward currents in single smooth muscle cells from the ureter of the guinea‐pig.1990 · 71 citations
  3. 3Two components of potassium current activated by depolarization of single smooth muscle cells from the rabbit portal vein.1989 · 169 citations
  4. 4Effects of tetraethylammonium and 4‐aminopyridine on outward currents and excitability in canine tracheal smooth muscle cells1990 · 64 citations
  5. 5Macroscopic K+ currents in single smooth muscle cells of the rabbit portal vein.1989 · 89 citations