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July 1, 1992AJP Cell Physiology

Outward currents in longitudinal colonic muscle cells contribute to spiking electrical behavior

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Population

isolated longitudinal colonic muscle cells

Comparison

Blockade of inward Ca2+ current… vs Baseline/control conditions

Design

Preclinical

Authors

KTK. D. ThornburyDundalk Institute of TechnologyMWManus W. WardKing Abdullah University of Science and TechnologyKSKenton M. SandersElectrophysiology

Discussion

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Implication

Differential K channel expression may explain layer-specific colonic motility; leaves open translation to human physiology or therapy.

Structured PICO

P
Population
isolated longitudinal colonic muscle cells
I
Intervention
Blockade of inward Ca2+ current, tetraethylammonium (TEA), and 4-aminopyridine (4-AP)
C
Comparator
Baseline/control conditions
O
Outcome
Ca(2+)-dependent and voltage-dependent K currents, and action potential amplitude and frequencysurrogate

Differences in electrical behavior between longitudinal and circular colonic muscle layers may be related to the expression of different species of potassium channels.

Cite This Study

Thornbury et al. (1992) studied this question.

synapsesocial.com/papers/6a89cbaa186271ac99334fd4https://doi.org/10.1152/ajpcell.1992.263.1.c237
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Two components of potassium current activated by depolarization of single smooth muscle cells from the rabbit portal vein.1989 · 169 citations
  2. 2Effects of tetraethylammonium and 4‐aminopyridine on outward currents and excitability in canine tracheal smooth muscle cells1990 · 64 citations
  3. 3Ionic basis of pacemaker generation in dog colonic smooth muscle.1989 · 38 citations
  4. 4Characteristics of transient outward currents in single smooth muscle cells from the ureter of the guinea‐pig.1990 · 71 citations
  5. 5A voltage‐dependent outward current with fast kinetics in single smooth muscle cells isolated from rabbit portal vein.1989 · 87 citations