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May 1, 1991AJP Cell Physiology

Relationship between calcium current and cytosolic calcium in canine gastric smooth muscle cells

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Population

Voltage-clamped, indo-1-loaded smooth muscle cells isolated from the circular layer of the canine antrum

Design

Preclinical

Authors

FVFivos VogalisAustralian National UniversityNPNelson G. PublicoverDalhousie UniversityJHJoseph R. HumeElectrophysiology

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Implication

Supports ICa-driven [Ca2+]i rise during gastric slow-wave plateau in canine myocytes; extends cellular mechanisms but leaves open human translation.

Structured PICO

P
Population
Voltage-clamped, indo-1-loaded smooth muscle cells isolated from the circular layer of the canine antrum
I
Intervention
Voltage-clamp protocols mimicking upstroke and plateau phases of slow waves
O
Outcome
Free intracellular Ca2+ concentration ([Ca2+]i) and Ca2+ current (ICa)surrogate

In canine gastric smooth muscle cells, calcium current during the plateau potential of slow waves is sufficient to cause a sustained increase in intracellular calcium.

Cite This Study

Vogalis et al. (1991) studied this question.

synapsesocial.com/papers/6a8385c8df262e78b072143ahttps://doi.org/10.1152/ajpcell.1991.260.5.c1012
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Total cytoplasmic calcium in relaxed and maximally contracted rabbit portal vein smooth muscle.1984 · 106 citations
  2. 2"Creep currents" in single frog atrial cells may be generated by electrogenic Na/Ca exchange.1986 · 86 citations
  3. 3Myoplasmic binding of fura-2 investigated by steady-state fluorescence and absorbance measurements1988 · 353 citations